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Antidepressant use was associated with a higher risk of head injuries especially at the beginning of use -- during the first 30 days -, but the risk persisted even longer, up to two years. The association was also confirmed in a study design comparing time periods within the same person, thus eliminating selective factors. The association with traumatic brain injuries was not as clear as for head injuries, which may be due to a smaller number of these events in the study population. The use of other psychotropic drugs did not explain the observed associations. Head injuries are more common among older people than younger ones, and they are usually caused by falling. As antidepressant use has previously been associated with an increased risk of falling, the researchers were not surprised that the use of antidepressants also increased the risk of head injuries. "However, our findings give cause for concern because persons with Alzheimer's disease frequently use antidepre...

Pink exhibits the place granulins are in cells, and inexperienced is LAMP1, a marker of lysosomes. Credit score: Chris Holler, Emory College College of Medication Emory College College of Medication researchers have developed instruments that allow them to detect small proteins known as granulins for the primary time inside cells. Granulins are of curiosity to neuroscientists as a result of mutations within the granulin gene trigger frontotemporal dementia (FTD). Nonetheless, the features of granulins have been beforehand unclear. FTD is an incurable neurodegenerative illness and the commonest sort of dementia in folks youthful than 60. Genetic variants within the granulin gene are additionally a threat issue for Alzheimer's illness and Parkinson's illness, suggesting this discovery could have therapeutic potential for a broad spectrum of age-related neurodegenerative ailments. The outcomes have been revealed August 9 by the journal  eNeuro . Some neuros...